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Electron Microscopy Sciences

Equipment

arrow13LYNX II Automated Tissue Processor for Histology and Microscopy

LYNX II Automated Tissue Processor for Histology and MicroscopyPDF download availableEMS is proud to announce the release of the most unique state-of-the-art tissue processor which not only is compatible with all plastic resins but paraffin waxes as well.

Introduction

LYNX II is designed to be the successor of Lynx Tissue Processor with several enhancements including capabilities to perform optional processing of larger size samples for Histology.

The LYNX II holds 24 reagent vials for EM processing. Optional HP (Histology processing) may be done with 12 larger size reagent vials for HP processing. In both EM and HP modes, LYNX II has two, independently controlled, heating/cooling stations.

Automated Tissue Processor for Histology and MicroscopyOperational Overview of LYNX II

LYNX II is a batch mode, tissue processing system. The tissues may be processed for EM or HP. Tissues of either type are processed in the same manner: Samples are mounted on the sample arm and reagents are loaded on the reagent carousel. Based on the selected program by the user, the LYNX II rotates the reagent carousel until the selected reagent station is at the processing station. At the processing station the sample is lowered in the reagent. Based on the selection of agitation and vacuum, the LYNX II periodically moves the sample arm to provide agitation and applies vacuum when the agitation is not in progress. Once the programmed time in a given reagent is over, the sample is raised and the next reagent is rotated in the processing station.

The operator may select the processing for EM or HP by the program numbers. Programs 1 through 10 are used for EM processing and programs 11-20 are used for HP processing. In addition to the proper program number selection, it is the responsibility of the end user to use the proper carousel positions and the appropriate type of reagent vials based on the selection of EM vs. HP processing. Once the unit is properly configured for EM or HP processing, the operator loads the reagent carousel and the samples, selects the desired program and starts the run.

At the end of the run, the sample is retained in the last reagent until the operator removes the sample.

Features

  • 12 reagent vials for HP processing, each 125 ml volume
  • 24 reagent vials for EM processing, each 25 ml volume
  • 10 Programs for EM and 10 programs for Histology
  • Two independently controlled heating/cooling stations
  • Easy replacement of reagent carousel
  • Paraffin Processing
  • Sample agitation
  • Vacuum infiltration during processing
  • Choice of plastic and metal containers for improved chemical compatibility and heat transfer
  • Optional external media based interface to a PC for ease of programming and allowing for the editing of programs on a PC and the transfer of programs between the LYNX II and the PC
  • Built-in fume extraction and ability to connect the discharge hose to lab exhaust system
  • Internal battery back-up during power fail to protect the samples
  • Ability to continue run after power interruption
  • User Friendly Operator Interface
  • Optional external UPS for continued processing during longer power outages

Functional Specifications

System Configuration

1. LYNX II is designed with the following functional modules.
  • Rotary mechanism to rotate the reagents
  • EM and HP reagent carousel
  • Up/Down mechanism to move the sample in and out of the reagent as well as to provide the agitation
  • EM and HP Sample arms
  • Tight seal for all reagent containers except for the one at the processing station.
  • Vacuum pump and a pressure sensor or a switch
  • Two Peltier operated heating/cooling station with independent temperature sensors and controls
  • Fume extraction fan and air flow sensor
2. Reagent Carousel

A reagent carousel may be installed, either a 24-position carousel for holding EM reagents or a 12-position carousel for holding HP reagents. The EM carousel holds cylindrical vials that are approx. 1.2" in diameter and 2.5" tall whereas HP vials are approx. 2.2" diameter (to hold 1.75" x 1.2" cassette flat) and 2.5" tall. The carousel is approx. 12" in diameter. Each vial has a flange for ease of handling. The vials are available in either plastic or aluminum. The vials may be mixed and matched between the metal and the plastic vials on a given carousel for certain kinds of processing.

The LYNX II has a built in sensor to detect that the proper reagent vial types (EM vs. HP) are installed on the unit before starting a run. Ability to detect only one of the two vial types is sufficient.

Sample Arm3. Sample Arm

The sample arm holds either an EM sample holder assembly or an HP sample holder assembly. Each sample holder assembly is designed to mount on the arm at a location to center the samples in its respective reagent container. The Sample Arm top may be changed to accommodate different samples.

4. Agitation and Vacuum

The arm provides a gentle agitation (approx. 5 mm up and down travel at a rate of 2.5 mm per second or one up/down agitation per second) once the sample is in the reagent container. Five agitation strokes are executed in 5 seconds and repeated every 45 seconds. If vacuum infiltration is selected, the agitation will be applied for 5 seconds followed by 40 seconds of vacuum. These agitation-only or the agitation-vacuum cycles will be repeated for the duration of the station time.

The sample holder assembly has a fitting to attach the vacuum hose from the vacuum pump.

5. Heating-Cooling Stations

The LYNX II provides 2 independent, identical heating-cooling stations (HCS). Each HCS is heated or cooled by a Peltier module and has its own temperature sensor. One HCS is located at the sample processing station and the second one is located one position prior to the sample processing station. This arrangement allows for the pre-heating or pre-cooling of the reagent for a program where the reagents are arranged in a sequential, contiguous manner.

Each HCS can be programmed to be between 4 deg. C and 65 deg. C. The accuracy of the actual temperature will be +/- 2 deg. C measured on the surface of the Heating – Cooling station. The set point at the HCS surface is reached within 7 minutes of the arrival of the reagent at the station.

6. Fume Control

LYNX II provides a fume extraction fan to direct fumes from the reagent/sample area to an exhaust port. An external hose may be connected to the unit and the hose may be directed to a fume hood or to laboratory exhaust system. The fume extraction is designed to ensure that the fumes are diverted away from electronics and the mechanism components.

Lid/Cover7. Lid/Cover

An acrylic cover with a latch is part of the fume control system. Controller of the system can detect if the cover is latched or not. By default, a run cannot be started (and will pause) if the cover is not in place. However,there is a software override will allow for the running of the unitt without closing the cover.

8. Seal for the Reagent Vials

A tight seal is provided to cover all reagent vials except for the one under the processing station.

Reagents Used

Materials for various components and subsystems of LYNX II is compatible with the following reagents during the processing.

HP Processing

  • Formalin
  • Alcohol
  • Xylene
  • Xylene Substitutes
  • Water
  • Paraffin
  • 10% bleach solution (to wipe clean the system)

EM Processing

  • Buffers
  • Osmium Tetroxide
  • Ethyl Alcohol
  • Acetone
  • Propylene Oxide
  • Epoxy/acrylic resins
9. Operation During Power Outage

The LYNX II contains a small internal battery (that is capable of moving the sample from up position to down position and to move the carousel in the next reagent position at least three times without being re-charged) to preserve the sample during a power outage. When the electronics in LYNX II detects that the A/C power is about to fail, the LYNX II will shut down the power to the Peltier elements at both heating/cooling stations. Next, it will ensure that the samples are down in a reagent container. If the samples are out of a reagent vial (since LYNX II was just about to rotate the carousel to the next reagent position or was in the middle of the rotation), the carousel will be rotated by one position and then the samples will be lowered in to the reagent at the processing station. The time when the power fail warning was activated will be recorded and the unit will go in the stand by mode.
Once the power is restored and is maintained for at least 30 seconds, LYNX II will resume the run. As LYNX II resumes run, the station time count down does not resume until the heating/cooling stations have reached the desired temperatures. The station time countdown does not begin for additional 60 minutes if the temperature at the processing station or at the previous station was above 55 deg. C during an HP run. This feature ensures that the paraffin at either of the two stations completely melts before moving to the next station

Specifications

Dimensions
Max Width: 22.5"
Max Depth: 19.0"
Max Height: 12.0" (cover closed)
Max Weight 50lb (32 kg)
Electrical Design
Display: 8 lines x 20 column text only LCD
Keypad: Membrane style keypad with tactile feed back
Mechanism Drive: Stepper Motors
Power Requirements: 100 - 115 volts AC, 50-60 Hz, 8 Amps Max
  230 volts AC, 50-60 Hz, 4 Amps Max
Back-up power: NiCd Battery, 12 volts, 1 Amp-hour
Fuse Rating:  
100 – 115 volt version 8 Amps x 250 Volts AC, Time Delayed (Slo-Blo)
230 volt version 5 Amps x 250 Volts AC, Time Delayed (Slo-Blo)
100 – 115 volt version 8 Amps x 250 Volts AC, Time Delayed (Slo-Blo)
230 volt version 5 Amps x 250 Volts AC, Time Delayed (Slo-Blo)
Operating Environmental Conditions
Ambient Temperature: 20 to 32 °C (70 to 90°F)
Relative Humidity: 20-80% non-condensing
Ambient Pressure: 28"-32" (70-80 mm) of Hg
Storage/Transportation Conditions
Temperature: 10-40 °C (50 to 102°F)
Humidity: 15%-80% non-condensing
Pressure: 28"-32" (70-80 mm) of Hg

Ordering Information

L12600 Lynx II for Microscopy* each 13,995.00 Add to Cart
L12601 Lynx II for Histology** each 13,750.00 Add to Cart
L12610 Histology Kit
(Histo Sample Holder, Histo Sample Arm, Histo Carousel, Power Cord, Operator Manual, Histo Aluminum Containers (24), Histo Plastic Containers (36), Plastic Caps (36), Exhaust Hose, Small Cassettes (100), 2 Sample Record Note Pads, Spare Fuses.
each 1,600.00 Add to Cart
L12612 L12612 Electron Microscopy Kit
(EM Sample Holder, EM Sample Arm, EM Carousel, Loading Jig, Power Cord, Operator Manual, Aluminum Containers (24), Plastic Containers (72), Plastic Caps (72), Exhaust Hose, Small Baskets (100), Large Baskets (100), Basket Lids (100), 2 Sample Record Note Pads, Spare Fuses
each 1,700.00 Add to Cart
L12602 Lynx II for EM and HP Combined*** each 15,000.00 Add to Cart
L12655 EM Reagent Vials, Bag of 72 each 170.00 Add to Cart
L12656 EM Regent Vial Cap, Bag of 72 each 170.00 Add to Cart
L12657 HP Reagent Vials, Bag of 36 each 100.00 Add to Cart
L12658 HP Reagent Vial Cap, Bag of 36 each 100.00 Add to Cart
L12937 Lynx II Rubber Bumpers 50/pk 75.00 Add to Cart
L12659 EM Aluminum Container (Box of 24) each 80.00 Add to Cart
L12660 HP Aluminum Container (Box of 12) each 45.00 Add to Cart
L13154 EM Sample Holder Assembly (Basket Stem Assembly) each 125.00 Add to Cart
L13154-OR O-Ring Assembly for Basket Stem 10/pk 3.95 Add to Cart
L12663 HP Cassette Holder Assembly each 350.00 Add to Cart
L12661 Vacuum Pump Tubing ( 1 each) each 30.00 Add to Cart
L12662 Vial Seal Assembly each 725.00 Add to Cart
L12673 Lynx II Exhaust Hose, 10' long each 70.00 Add to Cart
L12995 EM Sample Arm Seal each 70.00 Add to Cart
L12996 HP Sample Arm Seal each 70.00 Add to Cart
L12952 EM Carousel (Without Aluminum Containers) each 295.00 Add to Cart
L12953 HP Carousel (Without Aluminum Containers) each 290.00 Add to Cart
L12664 Replacement Back-up Battery each 135.00 Add to Cart
L12665 Lynx II Operator Manual each 20.00 Add to Cart
L12667 Lynx II Service Manual each 75.00 Add to Cart

loading jig*The Lynx II for Microscopy comes with: EM Sample Holder, EM Sample Arm, EM Carousel, Loading Jig (pictured right), Power Cord, Operator Manual, Aluminum Containers (24), Plastic Containers(72), Plastic Caps (72), Exhaust Hose, Small Baskets (100), Large Baskets (100), Basket Lids (100), 2 Sample Record Note Pads, Spare Fuses.

** The Lynx II for Histology comes with: Histo Sample Holder, Histo Sample Arm, Histo Carousel, Power Cord, Operator Manual, Histo Aluminum Containers (24), Histo Plastic Containers(36), Plastic Caps (36), Exhaust Hose, Small Cassettes (100), 2 Sample Record Note Pads, Spare Fuses.

***The Lynx II for Microscopy and Histology comes with everything found in both units .

All of the above accessories may be purchased separate or in the kit.

arrow11Lynx I Accessories and Replacement Parts (while supplies last)
300.0002 Disposable Basket Small 100/pk 96.00 Add to Cart
300.0003 Disposable Basket, Large 100/pk 90.00 Add to Cart
300.0005 Disposable Basket, Lid 100/pk 47.00 Add to Cart
300.0196 Disposable Basket, 8 Segment 100/pk 50.00 Add to Cart
300.0036 Disposable Vials 100/pk 152.00 Add to Cart
300.9011 Loading Jig each 160.00 Add to Cart
300.9017 Vial Lid Assembly each 48.00 Add to Cart
300.9010 Basket Stem & Foot Assembly each 112.00 Add to Cart
306.0830 Key each 6.00 Add to Cart
300.0041 Specimen Record Pad 3&4 Div. each 14.00 Add to Cart
300.8041 Exhaust Hose, 3 meter each 34.00 Add to Cart
300.0140 Disposable Vial Cap 100/pk 30.00 Add to Cart
300.9023 Vial Retaining Band each 42.00 Add to Cart
300.9513 Specimen Record Pad 8 Div each 14.00 Add to Cart
arrow11User Replaceable Parts
300.0139 User Manual each 25.00 Add to Cart
300.9016 Vial Seal Assembly each 425.00 Add to Cart

All of the above accessories are available for purchase separately upon request. Please call us for more information.

arrow11Consumables and Accessories
300.0005 Disposable Basket, Lid 100/pk 47.00 Add to Cart
300.0002 Disposable Basket Small 100/pk 96.00 Add to Cart
300.0041 Specimen Record Pad 3&4 Div. each 14.00 Add to Cart
300.9513 Specimen Record Pad 8 Div each 14.00 Add to Cart
300.8041 Exhaust Hose, 3 meter each 34.00 Add to Cart
300.9011 Loading Jig each 160.00 Add to Cart
300.0196 Disposable Basket, 8 Segment 100/pk 50.00 Add to Cart
300.0003 Disposable Basket, Large 100/pk 90.00 Add to Cart
arrow11Cassettes compatible with Lynx II
Micromesh™- Single Compartment Biopsy Processing / embedding Cassettesarrow11Micromesh™ Single Compartment Biopsy Processing / Embedding Cassettes with Lid

Made from acetyl polymer This new version of Micromesh™ offers 1676 square openings (0.38 mm) allowing for a greatly improved fluid exchange without having to use the biopsy pads. Large anterior and posterior slots in both cassette and cover ensure that the Micromesh™ biopsy cassettes will sink rapidly (far better than cloth mesh cassettes). A large square compartment measuring 27 mm is perfect even for needle biopsies. The cover does not protrude above the cassette, a great space saving feature allowing more cassettes to be stacked in automatic labeling machines and tissue processors.

  • These patented cassettes keep specimens safely submerged in liquid
  • Totally resistant to the most histological chemicals and solvents
  • The Micromesh™ ensures efficient fluid exchange and drainage
  • One-piece integral lid eliminates the need for separate steel lid
  • Lid is locked securely, no danger of specimen loss
  • Anterior writing area at a 45° angle – these cassettes are ideal for automated cassettes printers
  • Available in non-cytotoxic, non-metallic colors

Each case contains four dispenser boxes of 250 cassettes with covers.

70074-W 1-Compartment Micromesh™, White 1000/pk 236.00 Add to Cart
70074-P 1-Compartment Micromesh™, Pink 1000/pk 236.00 Add to Cart
70074-G 1-Compartment Micromesh™, Green 1000/pk 236.00 Add to Cart
70074-Y 1-Compartment Micromesh™, Yellow 1000/pk 236.00 Add to Cart
70074-B 1-Compartment Micromesh™, Blue 1000/pk 236.00 Add to Cart
70074-PE 1-Compartment Micromesh™, Peach 1000/pk 236.00 Add to Cart
70074-T 1-Compartment Micromesh™, Tan 1000/pk 236.00 Add to Cart
70074-GR 1-Compartment Micromesh™, Gray 1000/pk 236.00 Add to Cart
70074-L 1-Compartment Micromesh™, Lilac 1000/pk 236.00 Add to Cart
70074-O 1-Compartment Micromesh™, Orange 1000/pk 236.00 Add to Cart
70074-A 1-Compartment Micromesh™, Aqua 1000/pk 236.00 Add to Cart
70074-FY 1-Compartment Micromesh™, Fluo-Yellow 1000/pk 236.00 Add to Cart
Micromesh™- Four Compartment Biopsy Processing / embedding Cassettesarrow11MicroMesh™ Four-Compartment Biopsy Processing/Embedding Cassettes with Lid

This model is similar to the one above – single compartment – but cassettes have four square compartments each measuring 13 mm. Cover and base have about 1676 square openings maximizing fluid exchange and ensuring proper drainage. Each case contains four dispenser boxes of 250 cassettes with covers.

70075-W 4 Compartment Micromesh™, White 1000/pk 236.00 Add to Cart
70075-P 4 Compartment Micromesh™, Pink 1000/pk 236.00 Add to Cart
70075-G 4 Compartment Micromesh™, Green 1000/pk 236.00 Add to Cart
70075-Y 4 Compartment Micromesh™, Yellow 1000/pk 236.00 Add to Cart
70075-B 4 Compartment Micromesh™, Blue 1000/pk 236.00 Add to Cart
70075-PE 4 Compartment Micromesh™, Peach 1000/pk 236.00 Add to Cart
70075-T 4 Compartment Micromesh™, Tan 1000/pk 236.00 Add to Cart
70075-GR 4 Compartment Micromesh™, Gray 1000/pk 236.00 Add to Cart
70075-L 4 Compartment Micromesh™, Lilac 1000/pk 236.00 Add to Cart
70075-O 4 Compartment Micromesh™, Orange 1000/pk 236.00 Add to Cart
70075-A 4 Compartment Micromesh™, Aqua 1000/pk 236.00 Add to Cart
70075-FP 4 Compartment Micromesh™, Fluo-Pink 1000/pk 236.00 Add to Cart
70075-FG 4 Compartment Micromesh™, Fluo-Green 1000/pk 236.00 Add to Cart
70075-FY 4 Compartment Micromesh™, Fluo-Yellow 1000/pk 236.00 Add to Cart

Lynx Process Acceleratorarrow11Lynx Process Accelerator (LPA)

One on the most time consuming tasks during Paraffin processing is wax infiltration. Not a step to cut corners on unless you want to deal with poorly infiltrated blocks. The Lynx-LPA was designed to allow a greater through-put of specimens without compromising the critical infiltration step. Once your initial tissues reach the first paraffin step you can transfer the cassette holder to the Lynx-Pal for vacuum infiltration while you un-burden the Lynx to start another process cycle.

The LPA has 3 positions to accept three HP cassette holder which conveniently uses the same Aluminum vial as the Lynx processor to contain paraffin. Each Aluminum vial is fitted with a platform to allow the stir-bar to circulate the melted wax.

Processing time can be set between 1 and 180 minutes in variable increments. Temperature can be set between 40 and 65 deg. C in one degree C increments. Temperature is displayed in Deg C as a two digit number without any decimal point. The temperature accuracy at the sensor (and on the display) will be within +/- 2 deg. C. Vacuum off time can be between 0 and 3 minutes in 1 minute increments. Vacuum cycle runs as on time followed by the off time where 0 on time implies that no vacuum is necessary and 0 off time implies that vacuum must be on continuously. During sample processing the vacuum is applied as per on and off time selection. If the processing is paused, the vacuum is released within 15 seconds. At the end of the cycle time, the vacuum continues to be cycled and temperature is held at the desired point.

Specifications

Number of Paraffin Containers: 3
Temperature Range: 37° C - 75° C
Vacuum On Time: 0:30 To 3:00 (Min:Sec) in 30 second increments
Vacuum Off Time: 0:15 to 2:00 (min:sec) in 15 Second increments
Vacuum: Preset at factory, 5 (+/- 2 ) PSI below ambient
Temperature Accuracy: +/-2°C at the sensor at set point
Temperature Offset: -5 to +5°C
Process Time: 0:15 To 3:00 (hour:Min) in 15 minute increments
Stirring: Magnetic Stir Bar
Input Voltage: 100-230 Volts AC 50/60 Hz
Power: 150 Watts Max
LX12668 Lynx Process Accelerator (LPA) each 5,000.00 Add to Cart

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