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Electron Microscopy Sciences

Technical Data Sheets

Formaldehyde/Zinc Fixative

EMS Catalog #15675

Formaldehyde/Zinc Fixative Ready-to-use is designed to be used in your laboratory as a routine fixative, denaturing your tissue specimens and achieving cellular rigidity without over hardening.

Formaldehyde/Zinc Fixative retards protein crosslinking responsible for masking the immunochemistry antigenic binding sites. This fixative will yield excellent results in routing H&E, special stains, Enzymatic stains and immunochemical reactions.

Instructions for Use:

  • Formaldehyde/Zinc Fixative Ready-to-use is to be used full strength.
  • Use as routine histologic fixatives. For optimum results tissue/fixative ratio should not exceed 1:15 and specimens should be placed into fixative immediately following removal from the patient.
  • It may be used as the secondary fixative after neutral buffered formalin, providing that exposure to NBF has not exceeded several hours.
  • If used in enclosed tissue processors, it is advisable to follow manufacturers instructions in regards to flushing and housekeeping procedures.

DANGER: Strong sensitizer, avoid prolonged or repeated exposure. Use under fume hood and adequate ventilation.

CAUTION: The Federal Formaldehyde Standard requires that all containers be labeled with a warning listing all of the hazards of this solution.

DISPOSAL: Dispose in accordance to State and local codes. Disposal may be easier if Zinc is removed from solution. Simply raise the pH to 7.0 - 8.0 with a mild alkaline solution (sodium hydroxide is recommended). Wait several hours and filter the solution. Dispose of the filtered precipitate as you would any inorganic solids of low toxicity.

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Formaldehyde/Zinc Fixative