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Electron Microscopy Sciences

Technical Data Sheets

Publications Referencing the Antigen Retriever

EMS Catalog #62706

The Retriever Program began in 2003 based on novel, unique antigen unmasking automatic unit. The number of Retrievers worldwide has constantly grown; it is used in practically all countries and continents, and has become somewhat of an international standard for antigen unmasking. If you are considering whether to acquire your own Retriever, please see some of the experiments done in various types of research and clinical studies. These examples best illustrate what can be done with this machine and why hundreds are using it.

Cell Biology, Developmental Biology & Mouse Models

Molecular Biology of the Cell Vol. 20, 2572–2581, May 15, 2009
Regulation of Mammary Gland Branching Morphogenesis by EphA2 Receptor Tyrosine Kinase
David Vaught, Jin Chen, and Dana M. Brantley-Sieders

Mol Cancer Ther. 2008 Mar;7(3):590-8
Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in Apc(Min/+) mice.
Alferez D, Wilkinson RW, Watkins J, Poulsom R, Mandir N, Wedge SR, Pyrah IT, Smith NR, Jackson L, Ryan AJ, Goodlad RA.

Mol Cell Biol. 2004 Apr;24(7):2673-81.
Inhibition of Mist1 homodimer formation induces pancreatic acinar-to-ductal metaplasia.
Zhu L, Tran T, Rukstalis JM, Sun P, Damsz B, Konieczny SF.

Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10063-8
Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.
Kobielak K, Stokes N, de la Cruz J, Polak L, Fuchs E.

Science. 2010 Jun 4;328(5983):1278-81.
Meiotic recombination provokes functional activation of the p53 regulatory network.
Lu WJ, Chapo J, Roig I, Abrams JM.

Cancer Res. 2006 Jan 1;66(1):242-7.
Mist1-KrasG12D knock-in mice develop mixed differentiation metastatic exocrine pancreatic carcinoma and hepatocellular carcinoma.
Tuveson DA, Zhu L, Gopinathan A, Willis NA, Kachatrian L, Grochow R, Pin CL, Mitin NY, Taparowsky EJ, Gimotty PA, Hruban RH, Jacks T, Konieczny SF.

J Clin Invest. 2008 Jan;118(1):89-99.
Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells.
Aikawa T, Whipple CA, Lopez ME, Gunn J, Young A, Lander AD, Korc M.

Cancer Res. 2007 Jan 1;67(1):276-80.
Transgenic overexpression of RasGRP1 in mouse epidermis results in spontaneous tumors of the skin.
Oki-Idouchi CE, Lorenzo PS.

Cancer Pathology

Urology. 2006 Sep;68(3):578-82.
Inactivation of myopodin expression associated with prostate cancer relapse.
Yu YP, Tseng GC, Luo JH.

Acta Oncol. 2008;47(8):1539-45.
Aberrant expression of cyclin E in low-risk node negative breast cancer.
Ahlin C, Gruhne B, Holmqvist M, Zetterberg A, Fjällskog ML.

Breast Cancer Res Treat. 2010 Jul;122(2):315-24.
Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.
Rennstam K, McMichael N, Berglund P, Honeth G, Hegardt C, Rydén L, Luts L, Bendahl PO, Hedenfalk I.

Pancreas. 2009 Apr;38(3):259-66.
Neurogenin 3 and neurogenic differentiation 1 are retained in the cytoplasm of multiple endocrine neoplasia type 1 islet and pancreatic endocrine tumor cells.
Lejonklou MH, Edfeldt K, Johansson TA, Stålberg P, Skogseid B.

Leuk Lymphoma. 2010 Jul;51(7):1269-77.
Potential biomarkers of bortezomib activity in mantle cell lymphoma from the phase 2 PINNACLE trial.
Goy A, Bernstein SH, McDonald A, Pickard MD, Shi H, Fleming MD, Bryant B, Trepicchio W, Fisher RI, Boral AL, Mulligan G.

Horm Metab Res. 2008 May;40(5):354-9.
Lack of nuclear expression of hairy and enhancer of split-1 (HES1) in pancreatic endocrine tumors.
Johansson T, Lejonklou MH, Ekeblad S, Stålberg P, Skogseid B.

Clin Cancer Res. 2006 Jul 1;12(13):4080-9.
PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.
Soncini C, Carpinelli P, Gianellini L, Fancelli D, Vianello P, Rusconi L, Storici P, Zugnoni P, Pesenti E, Croci V, Ceruti R, Giorgini ML, Cappella P, Ballinari D, Sola F, Varasi M, Bravo R, Moll J.

Immunology, Research & Clinical

J Exp Med. 2009 Aug 3;206(8):1661-71.
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.
Espinosa A, Dardalhon V, Brauner S, Ambrosi A, Higgs R, Quintana FJ, Sjöstrand M, Eloranta ML, Ní Gabhann J, Winqvist O, Sundelin B, Jefferies CA, Rozell B, Kuchroo VK, Wahren-Herlenius M.

Bone Marrow Transplant. 2008 Dec;42(12):807-18.
GVHD after chemotherapy conditioning in allogeneic transplanted mice.
Sadeghi B, Aghdami N, Hassan Z, Forouzanfar M, Rozell B, Abedi-Valugerdi M, Hassan M.

J Reprod Immunol. 2010 Mar;84(2):176-85.
Pro-inflammatory and anti-inflammatory cytokines in human preterm and term cervical ripening.
Dubicke A, Fransson E, Centini G, Andersson E, Byström B, Malmström A, Petraglia F, Sverremark-Ekström E, Ekman-Ordeberg G.

Virology and Microbiology

Virology. 2009 Oct 25;393(2):338-45.
An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice.
Memoli MJ, Tumpey TM, Jagger BW, Dugan VG, Sheng ZM, Qi L, Kash JC, Taubenberger JK.

mBio 2010 1(1):e00067-10. doi:10.1128.
The PB2-E627K mutation attenuates viruses containing the 2009 H1N1 influenza pandemic polymerase.
Jagger, B. W., M. J. Memoli, Z.-M. Sheng, L. Qi, R. J. Hrabal, et al.

PLoS One. 2009 Jun 16;4(6):e5916.
Infectious prions in pre-clinical deer and transmission of chronic wasting disease solely by environmental exposure.
Mathiason CK, Hays SA, Powers J, Hayes-Klug J, Langenberg J, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, Mason GL, Hoover EA.

J Virol. 2009 Apr;83(8):3754-61.
Role of sialic acid binding specificity of the 1918 influenza virus hemagglutinin protein in virulence and pathogenesis for mice.
Qi L, Kash JC, Dugan VG, Wang R, Jin G, Cunningham RE, Taubenberger JK.


J Comp Neurol. 2008 Sep 1;510(1):79-99.
Distinct molecular pathways for development of telencephalic interneuron subtypes revealed through analysis of Lhx6 mutants.
Zhao Y, Flandin P, Long JE, Cuesta MD, Westphal H, Rubenstein JL.


Journal of Investigative Dermatology (2005) 124, 615–621.
Mutations in Gasdermin 3 Cause Aberrant Differentiation of the Hair Follicle and Sebaceous Gland.
Declan P Lunny, Erica Weed, Patrick M Nolan, Andreas Marquardt, Martin Augustin and Rebecca M Porter.

Reproductive Biology & Endocrinology

Fertility & Sterility. Vol 91, Issue 4, Supplement, Pages 1420-1423 (April 2009).
Expressions of steroid receptors and Ki67 in first-trimester decidua and chorionic villi exposed to levonorgestrel used for emergency contraception.
Chun-Xia Meng, M.D.ab, Li-Nan Cheng, M.D.b, Parameswaran Grace Luther Lalitkumar, Ph.D.a, Lin Zhang, M.D.b, Hui-Juan Zhang, M.D.b, Kristina Gemzell-Danielsson, M.D., Ph.D.

Hum Reprod. 2010 Apr;25(4):874-83.
Effects of oral and vaginal administration of levonorgestrel emergency contraception on markers of endometrial receptivity.
Meng CX, Marions L, Byström B, Gemzell-Danielsson K.

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Antigen Retriever